Pharmacovigilance (PV) is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. With exponential growth in data volume and complexity, traditional PV methods are inadequate. By adopting a multifaceted approach and applying the latest technological advancements, the PV process can be challenged. Automation and Artificial Intelligence (AI) offer the transformative potential to enhance PV activities' efficiency, accuracy, and comprehensiveness.